Servicemen from countries including Germany, Canada, Estonia and the US will join the Latvian armed forces in the exercises between 17-30 April.
The Baltic nation joined the bloc in 2004, and has used its territory for drills with partner states ever since.
This comes as US President Donald Trump appeared to perform a dramatic u-turn on his Nato stance when he met Theresa May at the White House on Friday.
The billionaire Republican was an outspoken critic of the alliance during his bid for the presidency last year, arguing smaller member states were failing to pay their fair share.
But the Prime Minister announced her and the President had reaffirmed their commitment to the collective defence force after their meeting.
She confirmed Trump was “100 per cent behind Nato” – despite the President recently deriding the organisation as “obsolete”.
The Prime Minister said: “On defence and security cooperation, we’re united in our recognition of Nato as the bulwark of our collective defence, and today we’ve reaffirmed out unshakable commitment to this alliance.
Turning to the President, Mrs May continued: “Mr President, I think you said, you confirmed that you’re 100 per cent behind Nato.”
The Republican also reasserted the importance of smaller states making adequate contributions during a phone call with German chancellor Angela Merkel on Saturday.
The two leaders agreed on the importance of Nato during the call – but the President made clear his position on financial contributions.
Trump’s shift on Nato now puts him in step with the views of US Secretary of Defence James Mattis, who made a point to make clear the importance of the alliance on his first day as head of the Pentagon.
The former US Marine Corps general has spoken to defence officials from other member states confirming the “unshakable” commitment of the US to its cause.