Fire crews have been trying to tame the blaze which sent up thick black smoke after the crash at 8:40pm GMT (1:40pm local time), leaving one Santa Fe neighbourhood power line hanging midair.
Within two hours, buildings within the industrial park of the US plastics recycling company, Multi-Link Corp were completely destroyed, including several shipping containers.
Sergeant Dominic Iraldo, from the Whittier Police Department, said no injuries have yet been reported.
The police added that the collision destroyed local power lines, sheared a hydrant and caused the fire.
Sergeant Iraldo went on to explain that police were evacuating neighbouring buildings as firefighters continue to tackle the flames.
Describing the scene, Michael Crook, Santa Fe Springs Fire Chief said: “We had wires down and we had a sheered hydrant. So we had a 30-foot geyser and a lot of water going down the street.
“Wires were down and we couldn’t make access. There was a loss of water supply, but we overcame it.”
Officials estimated at least 60 people to be inside the recycling plant when the fire started.
Four hours after the crash, firefighters confirmed that they had taken control of the fire which destroyed at least three buildings at the recycling plant.
One firefighter sustained a minor ankle injury while tackling the blaze but all other 60 onlookers were evacuated safely.